Grazie al recente articolo di seguito, vengono analizzati i rapporti fra microbiota intestinale e sistema immunitario mucosale.
I rapporti fra microbiota intestinale e sistema immunitario mucosale
Mucosal immunity and gut microbiota in dogs with chronic enteropathy
Department of Immunology, University of Manitoba, Winnipeg, MB, Canada
Department of Food Science and Technology, University of Nebraska-, Lincoln, NE, USA
João Carlos Gomes-Netoc
Nebraska Food for Health Center, Department of Food Science and Technology, University of Nebraska, Lincoln, NE, USA
Department of Parasitology and Animal Diseases, Veterinary Research Division, National Research Centre, Giza, Egypt
Research in Veterinary Science (Volume 122, February 2019, Pages 156-164)
Chronic enteropathy (CE) in dogs is a chronic and relapsing immunopathology, of unknown etiology, that usually manifests with a plethora of clinical signs reflecting the underlying heterogeneity in its pathogenesis. Alterations of the mucosal immune responses and the gut microbiota composition are thought to play an essential role in CE. Similar to humans, it is hypothesized that the breakdown in mucosal tolerance leads to aberrant and pathological immune responses toward the gut microbiota, that in turn, may contribute to the severity of disease, at least for certain CE subsets. Therefore, in this review, we discuss some of the most relevantand recent insights microbiological and immunological aspects characterizing CE in dogs.