By the scientific direction of NBF – LANES with the advice of Dr. M. Cornelli

There are special situations in which the body, to meet its requirements, requires an extra amount of Nucleic Acids or Nucleotides. Usually, it comes to metabolic stress conditions which require the administration of external origin elements, with considerable acceleration of recovery.

Premessa

I Nucleotidi sono elementi intracellulari, che svolgono un ruolo chiave nella quasi totalità dei processi biochimici; essi rappresentano gli elementi precursori del DNA e dell’ RNA, e sono composti da uno zucchero ed una base, associati a un certo numero di gruppi fosfato (da uno a tre).
I Nucleotidi sono naturalmente presenti in tutti i cibi, sia di natura animale sia vegetale, sotto forma di acidi nucleici o nucleotidi liberi; in particolare i Nucleotidi solubili, presenti nel latte di molti mammiferi, costituiscono un’importante fonte alimentare, in grado di fornire fino al 20% dell’azoto non proteico. Read more

Dr. Barbara Tonini (*) DVM, freelance, Milan

FIV infection may remain subclinical for long periods, so without causing any symptoms, but leads to the development of clinical manifestations such as, generalized lymphadenopathy, diarrhea, anorexia, fever, weight loss, chronic infections, neurological disorders and cancers.

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Dr.Paola Persico

Recent studies have now confirmed as immunology and nutrition are closely related. Many substances such as arginine, glutamine, zinc, Omega-3 fatty acids and nucleotides improve the cellular immunity, modulate the metabolism of cancer cells and promote clinical recovery.

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Chiara Noli, Mario Galzerano, Stefano Toma. From SUMMA Pets, n.9-2009, 21-27
Summary by the scientific editors NBF-Lanes

The hypothesis of the authors is that if the higher omega-6 and omega-3 PUFAs are administered before the inflammatory response it triggers, then anti-inflammatory or less inflammatory eicosanoids are produced with lower anti-inflammatory power of those that would be produced without the supplementation.

THE AIM OF THIS STUDY IS THE EVALUATION OF THE ORAL SUPPLEMENTATION OF BLACK CURRANT OIL (BSO) (100 MG / KG / DAY), PLACEBO-CONTROLLED, FOR THE PREVENTION OF RECURRENCE OF THE SYMPTOMS OF ATOPIC SEASONAL DERMATITIS IN DOGS.

IN THE 7 TREATED ANIMALS ITCHING AND LESIONS WERE LOWER THAN THE PREVIOUS YEAR IN ALL SUBJECTS, WHILE IN THE CONTROL GROUP LESIONS WERE LOWER THAN IN PREVIOUS YEARS ONLY IN 3/7 DOGS

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By the Scientific Writing of NBF-Lanes with the collaboration of Dr. Maurizio Cornelli

We examined the relationship between plasma levels of PUFA and total change in creatinine clearance during three years of follow-up, in older people enrolled in “inCHIANTI” study, an epidemiological study based on the population and conducted in Tuscany, Italy.

This study has shown that older adults with low plasma levels of total PUFA have a greater decrease in creatinine clearance. These results suggest that increased dietary intake of PUFA may be protective against the progression to chronic kidney disease.

THIS RUNDOWN ON THE NEW FRONTIERS OF CHRONIC KIDNEY DISORDERS, GIVEN THE MEDICAL EXTRACTION OF THE AUTHORS, FOCUSES ON WHAT HAPPENS IN THE HUMAN FIELD, BUT HAS INTERESTING PARALLELS WITH THE SAME TYPE OF DISTURBANCE DETECTED IN THE VETERINARY FIELD. THE AUTHORS MAKE CONTINUAL REFERENCES TO OUR SECTOR, FROM WHICH DRAWS ON ALL THE EXPERIMENTAL CASES.

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By the scientific direction of the NBF-Lanes with the advice of Dr. Fabrizio Fabbrini.

Atopic dermatitis, as it is a chronic disease of genetic base, cannot be eliminated but managed by setting a nutritional therapy that can alleviate the symptoms and lesions, prevent secondary infections and increase the quality of life, both to the patient and his owner.

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Yurico Adkins, Darshan S. Kelley
Western Human Nutrition Center, ARS, USDA, University of California Davis, CA 95616, USA Department of Nutrition, University of California Davis, CA 95616, USA Journal of Nutrition Biochemistry 21 (2010) 781-792

BASED ON THE RESULTS OF CELLULAR AND MOLECULAR STUDIES, THE CARDIOPROTECTIVE EFFECTS OF POLYUNSATURATED FATTY ACIDS OMEGA 3 DOES NOT SEEM ATTRIBUTABLE TO A SINGLE SYSTEM, BUT TO A TRUE INTEGRATED ACTION WHICH, IN ADDITION TO THE “SIMPLE” GOOD FUNCTIONING OF THE HEART PUMP, EXTENDS TO THE INTEGRITY OF VASCULAR COMPONENT AND THE OPTIMIZATION OF THE PRECIOUS FLUID THAT FLOWS.

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Scientific direction of NBF Lanes in cooperation with Prof. Sebastiano BANNI, University of Cagliari.

 WHAT IS THE CLA

THE CONJUGATED LINOLEIC ACID (CLA) IS A LONG-CHAIN FATTY ACID

The conjugated linoleic acid (CLA) is a long-chain fatty acid formed by a mixture of several isomers; two particularly active forms have been identified: cis-9, trans-11 and trans-10, cis-12. CLA occurs naturally in dairy products and meat from ruminants.

HIGH NUMBER OF EXPERIMENTS FOR BIOLOGICAL ACTIVITY

The great attention paid to Conjugated Linoleic Acid (CLA) is due to the large number of experiments that have revealed several important biological activity of this long-chain fat acid such as:

Modulation of lipid metabolism

Anticancer activity

Modulation of the immune system

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In the ‘50s Hugh Sinclair suggested that many chronic diseases, particularly those in the Western civilization (cardiovascular, inflammatory and neoplastic), were to be correlated to a relative deficiency in essential fatty acids.
The Sinclair hypothesis has proved to be fundamentally correct.
In the last two decades the essential fatty acids (EFA), for their importance in many body functions, have been the subject of great attention both from doctors, researchers, and the general public.
In fact the use of the EFA in medicine dates back to the ’30s, when they were used for the first time in the treatment of infant atopic eczema (1).
Despite their use were promising, they were quickly ignored with the advent of the topical corticosteroids.
Sinclair suggested that Western affluent populations, feeding diets with a high content of polyunsaturated fatty acids EFA, went to meet him to a decrease in the composition in EFA of their body such as to prevent the structural and physiological functions related to these fatty acids. Sinclair hypothesis, at that time considered ridiculous and without fundaments, in light of subsequent research has proved to be fundamentally correct (3.4).

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Leishmaniosis is basically characterized by an anomaly antigen response to an altered immune system function. It therefore seems logical to assume that the use of such immune-stimulant substances, either alone or associated with traditional medication, can favorably influence the outcome of therapy. The results show that both types of Leishmaniae are sensitive to zinc sulphate.

Notes on the biological cycle of Leishmania
The infection is transmitted by the bite of infected sandflies. The promastigotes (flagellates elements, extracellular) in the insect’s saliva, penetrate through the skin, bind to macrophages of the skin and spread in the reticuloendothelial system of the whole organism. On the surface of the promastigote there are two molecules that have a prominent role in engaging the parasite-phagocytic cells: a glycoprotein (gp63) and a lipofosfoglycan. They activate the way alternates complement. Most parasites are destroyed by the body’s non-specific defenses, some are rapidly engulfed by macrophages, where they become amastigotes (aflagellati elements, intracellular), which begin to multiply in intracellular vacuoles. The amastigotes are oval forms of 2-4 microns in diameter. The lysosomes of macrophages release the hydrolasic enzymes to digest the parasite, Leishmania but offer some resistance to their action. Visceral leishmaniosis in the affected cells are soon to meet death and release the amastigotes that are themselves engulfed by other macrophages: this cycle is repeated several times until all organs containing macrophages are widely infected with Leishmaniae (spleen, liver, bone marrow, lymph nodes). When a subject is infected point from another phlebotomist not yet infected, the infection is transmitted at the time when it sucks the blood, through the circulating macrophages full of amastigotes. In the sandfly stomach amastigotes are released in a few hours and intestines are transformed into promastigotes, 10-15 microns long plagued shape and 1.5-3.5 microns wide: the scourge measures 15-28 microns. After many binary divisions they migrate into the pharynx and in the buccal cavity of the sandfly, ready to be placed on a new host. The cycle time in the mosquito is ten-day.

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