Dr.Claudio Brovida, Dr. Stefania Ceretto
In the dynamic stage renal disease, the progressive loss of function that leads to renal failure, is characterized by an evolution compensating survivors of nephrons, which are subject to hypertrophy (mega nephrons). This evolution is the body’s natural response to the need to compensate the increase of blood hydrostatic pressure of capillaries, of the glomerular filtration rate (GFR) index due to a reduction of kidney filtering surface. In addition to the already mentioned hypertrophy, hypertension and glomerular hyper filtration also occur.