The administration of GLA, present in high doses in the Black Currant seeds oil, promotes two precious activities into the cell:
- immunomodulatory
- anti-inflammatory
Immunomodulatory activities: The Prostalgandine PGE1 are capable of modulating the cellular immune reaction and reduce the activity of lymphocytes T-helpher 2 (Th2). In particular, in Atopic Dermatitis, the Th2 response leads to a diverted immune reaction, characterized by an overproduction of IgE and, consequently, of Histamine.
Anti-inflammatory activity: Diomo-Gamma Linolenic Acid, acting in synergy with the Omega-3 long chain fatty acids, is able to reduce the formation of inflammatory prostaglandins (PGE2) and inflammatory leukotrienes (LTB4), metabolites of arachidonic acid (AA), as well as to inhibit the production of interleukins (IL-1) and of Proinflammatory Cytokines (TNF-Alpha).
