GLA

Gamma Linoleic Acid with anti-inflammatory and immunomodulatory effects

Definition

The GLA is an Omega-6 Long Chain Fatty Acid with 18 carbon atoms, direct precursor of Diomo-Gamma Linolenic and anti-inflammatory eicosanoids with 20 atoms of carbon (PGE1 Prostaglandins, Leukotrienes LTB3 and thromboxanes TXA1).

Biological Role

The administration of GLA, present in high doses in the Black Currant seeds oil, promotes two precious activities into the cell:

  • immunomodulatory
  • anti-inflammatory

Immunomodulatory activities: The Prostalgandine PGE1 are capable of modulating the cellular immune reaction and reduce the activity of lymphocytes T-helpher 2 (Th2). In particular, in Atopic Dermatitis, the Th2 response leads to a diverted immune reaction, characterized by an overproduction of IgE and, consequently, of Histamine.

Anti-inflammatory activity: Diomo-Gamma Linolenic Acid, acting in synergy with the Omega-3 long chain fatty acids, is able to reduce the formation of inflammatory prostaglandins (PGE2) and inflammatory leukotrienes (LTB4), metabolites of arachidonic acid (AA), as well as to inhibit the production of interleukins (IL-1) and of Proinflammatory Cytokines (TNF-Alpha).

Clinical Applications

The latest scientific researches suggest that different diseases with inflammatory and/or immune origin, such as atopic dermatitis, are characterized by:

  1. A) an excessive presence in the cell membrane of arachidonic acid, resulting in accumulation of inflammatory metabolites
  2. B) a deficiency in GLA which has immunomodulatory and anti-inflammatory activity

In Atopic Dermatitis the GLA intake at a dose of 15 mg / kg:

  • Improves the GLA/AA ratio
  • Promotes the formation of PgE1 and contrasts the synthesis of inflammatory PGE2
  • Balances the immune response, reducing Th2 lymphocytes in favor of Th1
  • Limits the overproduction of IgE resulting in a reduced release of histamine

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